CYP26B1

Across TCGA pan-cancer cohorts, CYP26B1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CYP26B1 data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CYP26B1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYP26B1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and DLBC show a favorable association.

ACC, SCLC, and DLBC are the cancer types where CYP26B1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.156	0.819	<.001	109	view →
SCLC	DFS	Quartile	All	0.613	0.245	.001	31	view →
DLBC	DFS	Tertile	IV	0.943	0.184	.010	26	view →
LIHC	OS	Quartile	All	0.553	0.725	.005	23	view →
UCEC	DFS	Median	All	0.508	0.765	.002	22	view →
THCA	DFS	Quartile	IV	0.923	0.495	.021	13	view →
STAD	DFS	Quartile	III,IV	0.447	0.775	.009	12	view →
LUSC	DFS	Tertile	II,III,IV	0.474	0.778	.021	11	view →
BLCA	DFS	Tertile	III,IV	0.330	0.588	.008	11	view →
KICH	OS	Quartile	III,IV	0.468	1.000	.016	10	view →
UVM	OS	Quartile	III,IV	0.530	1.000	.026	9	view →
GBM	OS	Tertile	All	0.342	0.472	.034	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CYP26B1–ACC (DFS)

Open the ACC breakdown →