CYP26A1

Across TCGA patient cohorts, CYP26A1 mutation is significantly associated with the RNA expression of many other genes, with 3,061 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP26A1-associated genes across cancer lineages are RPL23AP33, MTND4LP3, and BCL2L2-PABPN1. Each is linked with CYP26A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP26A1-to-partner and partner-to-CYP26A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP33 grouped by CYP26A1-low versus CYP26A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP26A1→partner) and Y-score (partner→CYP26A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL23AP33 →	+0.133	+4.225	<.001	.007	3	2
BLCA	MTND4LP3 →	+0.187	+7.040	<.001	<.001	3	2
UCEC	BCL2L2-PABPN1 →	+0.194	+2.533	.006	.009	3	2
UCEC	BNIP3 →	+0.893	+2.263	<.001	<.001	3	2
UCEC	RPL26L1 →	+0.491	+2.295	<.001	<.001	3	2
CESC	LINC01519 →	+0.024	+5.669	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,061 associations by consensus.

RPL23AP33 by CYP26A1 expression — COAD

Explore this box plot interactively →