CYP26A1

Across TCGA patient cohorts, CYP26A1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP26A1-associated genes across cancer lineages are eIF4E, HER3, and JNK2. Each is linked with CYP26A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP26A1-to-partner and partner-to-CYP26A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CYP26A1-low versus CYP26A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP26A1→partner) and Y-score (partner→CYP26A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.152	+2.115	.041	.017	3	2
UCEC	HER3 →	-0.232	-1.990	.017	.030	3	2
UCEC	JNK2 →	+0.199	+1.710	.004	.025	3	2
UCEC	Annexin-1 →	+0.486	+2.242	.008	.005	3	2
UCEC	Shc_pY317 →	-0.174	-2.321	.001	.005	3	2
UCEC	ATM →	-0.325	-1.362	.042	.037	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

eIF4E by CYP26A1 expression — UCEC

Explore this box plot interactively →