CYP26A1

Across TCGA cell cohorts, CYP26A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,166 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CYP26A1-associated GO terms across cancer lineages are Cytoplasmic translation, Purine nucleobase biosynthetic process, and Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Each is linked with CYP26A1 in more than 7 cancer types. Because this analysis shows association rather than direction, both CYP26A1-to-partner and partner-to-CYP26A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic translation grouped by CYP26A1-low versus CYP26A1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP26A1→partner) and Y-score (partner→CYP26A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Cytoplasmic translation →	+0.076	+0.614	.003	.002	3	8
BLOOD_Lymphoma	Purine nucleobase biosynthetic process →	+0.099	+0.748	<.001	.003	3	7
BLOOD_Myeloma	Regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.083	+2.667	<.001	.004	3	7
OESOPHAGUS	Cellular respiration →	+0.084	+1.193	<.001	<.001	3	7
OVARY	Nucleotide biosynthetic process →	+0.063	+0.609	.001	.009	3	7
OESOPHAGUS	Regulation of RNA export from nucleus →	+0.079	+1.204	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,166 associations by consensus.

Cytoplasmic translation by CYP26A1 expression — OVARY

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