CYP20A1

Across TCGA patient cohorts, CYP20A1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP20A1-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and VHL. Each is linked with CYP20A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP20A1-to-partner and partner-to-CYP20A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CYP20A1-low versus CYP20A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP20A1→partner) and Y-score (partner→CYP20A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.710	+2.189	.006	.034	3	3
UCEC	eIF4E →	+0.212	+2.115	.021	.019	3	2
UCEC	VHL →	-1.258	-2.000	<.001	.030	3	2
UCEC	ERK2 →	+0.172	+2.999	.041	.035	3	1
UCEC	Fibronectin →	-0.303	-2.115	.035	.019	3	1
UCEC	FoxM1 →	+0.297	+2.115	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Caspase-7-cleavedD198 by CYP20A1 expression — UCEC

Explore this box plot interactively →