CYP20A1

Across TCGA pan-cancer cohorts, CYP20A1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CYP20A1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CYP20A1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP20A1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LIHC are the cancer types where CYP20A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP20A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.713	<.001	11	view →
KICH	Male	II,III,IV	−1.027	<.001	10	view →
LIHC	Female	II,III,IV	+0.585	<.001	8	view →
BLCA	Male	All	−0.547	.002	7	view →
LUSC	Male	All	−0.417	<.001	7	view →
KIRC	Male	All	−0.302	<.001	6	view →
BRCA	Female	All	−0.162	.011	4	view →
CHOL	Male	All	+0.901	<.001	2	view →
KIRP	Male	All	−0.438	.001	2	view →
UCEC	All	All	−0.381	.022	2	view →
LUAD	Female	II,III,IV	−0.307	.038	2	view →
STAD	Male	II,III,IV	+0.489	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CYP20A1–THCA

Open the THCA breakdown →