CYP20A1

Across TCGA cell cohorts, CYP20A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,084 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CYP20A1-associated GO terms across cancer lineages are Negative regulation of mitotic sister chromatid separation, Negative regulation of sister chromatid segregation, and Negative regulation of mitotic sister chromatid segregation. Each is linked with CYP20A1 in more than 10 cancer types. Because this analysis shows association rather than direction, both CYP20A1-to-partner and partner-to-CYP20A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mitotic sister chromatid separation grouped by CYP20A1-low versus CYP20A1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP20A1→partner) and Y-score (partner→CYP20A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Negative regulation of mitotic sister chromatid separation →	+0.163	+0.763	.002	.002	3	11
KIDNEY	Negative regulation of sister chromatid segregation →	+0.163	+0.763	.002	.002	3	11
KIDNEY	Negative regulation of mitotic sister chromatid segregation →	+0.163	+0.763	.002	.002	3	11
KIDNEY	Negative regulation of mitotic metaphase/anaphase transition →	+0.163	+0.763	.002	.002	3	11
BLOOD_Lymphoma	Positive regulation of endoplasmic reticulum tubular network organization →	+0.069	+0.514	<.001	.005	3	10
BLOOD_Lymphoma	Regulation of ATP-dependent activity →	+0.078	+0.694	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,084 associations by consensus.

Negative regulation of mitotic sister chromatid separation by CYP20A1 expression — KIDNEY

Explore this box plot interactively →