CYP20A1

Across TCGA cell cohorts, CYP20A1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP20A1-associated genes across cancer lineages are BPIFB6, OR1L6, and MAGEB10. Each is linked with CYP20A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP20A1-to-partner and partner-to-CYP20A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFB6 grouped by CYP20A1-low versus CYP20A1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP20A1→partner) and Y-score (partner→CYP20A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	MAGEB10 →	+0.087	+3.930	<.001	.003	3	1
LARGE_INTESTINE	OR6B2 →	+0.034	+4.054	<.001	.004	3	1
LARGE_INTESTINE	DEFB134 →	+0.019	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

BPIFB6 by CYP20A1 expression — LARGE_INTESTINE

Explore this box plot interactively →