CYP1B1

Across TCGA patient cohorts, CYP1B1 mutation is significantly associated with the RNA expression of many other genes, with 3,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP1B1-associated genes across cancer lineages are FSCB, RNA5SP250, and RNU6-910P. Each is linked with CYP1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP1B1-to-partner and partner-to-CYP1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FSCB grouped by CYP1B1-low versus CYP1B1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1B1→partner) and Y-score (partner→CYP1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FSCB →	+0.040	+4.685	<.001	.003	3	2
HNSC	RNA5SP250 →	+0.235	+4.505	.001	.009	3	2
HNSC	RNU6-910P →	+0.488	+4.452	<.001	.006	3	2
HNSC	RNU2-47P →	+0.280	+5.468	<.001	.002	3	2
COAD	RPL17-C18orf32 →	+0.132	+3.747	<.001	.006	3	2
LUAD	RN7SL205P →	+0.471	+4.990	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,079 associations by consensus.

FSCB by CYP1B1 expression — HNSC

Explore this box plot interactively →