CYP1B1

Across TCGA pan-cancer cohorts, CYP1B1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CYP1B1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CYP1B1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYP1B1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where CYP1B1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYP1B1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.669	<.001	11	view →
KICH	Female	III,IV	−4.026	<.001	10	view →
THCA	Male	IV	+3.713	<.001	10	view →
UCEC	All	All	−3.800	<.001	6	view →
KIRP	All	All	−1.158	<.001	6	view →
LIHC	All	All	+0.785	.004	5	view →
BLCA	Female	III,IV	−2.051	.020	3	view →
STAD	All	All	−0.806	.033	3	view →
COAD	Female	All	−0.578	.016	3	view →
READ	Female	All	−1.946	.001	2	view →
LUAD	All	IV	−1.634	.036	2	view →
PAAD	All	All	−1.202	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CYP1B1–KIRC

Open the KIRC breakdown →