CYP1B1

Across TCGA patient cohorts, CYP1B1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP1B1-associated genes across cancer lineages are eEF2, PDCD4, and PKC-delta_pS664. Each is linked with CYP1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP1B1-to-partner and partner-to-CYP1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CYP1B1-low versus CYP1B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1B1→partner) and Y-score (partner→CYP1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.424	+2.321	.003	.033	3	2
UCEC	PDCD4 →	-0.698	-3.584	<.001	.002	3	2
UCEC	PKC-delta_pS664 →	-0.114	-3.321	.018	.009	3	2
UCEC	Annexin-1 →	+0.765	+3.604	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.883	+2.720	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.127	-2.558	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

eEF2 by CYP1B1 expression — UCEC

Explore this box plot interactively →