CYP1B1

Across TCGA cell cohorts, CYP1B1 mutation is significantly associated with the RNA expression of many other genes, with 489 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP1B1-associated genes across cancer lineages are OR4K1, CBY1, and TNRC6B. Each is linked with CYP1B1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP1B1-to-partner and partner-to-CYP1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K1 grouped by CYP1B1-low versus CYP1B1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP1B1→partner) and Y-score (partner→CYP1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4K1 →	+0.015	+4.977	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.801	+3.588	<.001	<.001	3	1
LARGE_INTESTINE	TNRC6B →	+0.729	+3.064	.001	.009	3	1
LARGE_INTESTINE	KCTD17 →	+1.082	+3.502	<.001	.001	3	1
LARGE_INTESTINE	L3MBTL2 →	+0.643	+3.169	<.001	.006	3	1
LARGE_INTESTINE	USP14 →	+0.634	+3.237	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 489 associations by consensus.

OR4K1 by CYP1B1 expression — SOFT_TISSUE

Explore this box plot interactively →