CYP19A1

Across TCGA patient cohorts, CYP19A1 mutation is significantly associated with the RNA expression of many other genes, with 2,712 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP19A1-associated genes across cancer lineages are MED19, BOLA3, and ZFYVE19. Each is linked with CYP19A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP19A1-to-partner and partner-to-CYP19A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED19 grouped by CYP19A1-low versus CYP19A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP19A1→partner) and Y-score (partner→CYP19A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MED19 →	+0.342	+1.491	.001	.008	3	3
UCEC	BOLA3 →	+0.306	+2.415	.008	.003	3	3
UCEC	ZFYVE19 →	+0.431	+2.523	<.001	<.001	3	3
UCEC	SCNN1B →	-1.484	-2.000	<.001	.001	3	3
LUAD	PRAMEF13 →	+0.039	+6.342	<.001	<.001	3	3
UCEC	GTSE1 →	+0.680	+3.711	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,712 associations by consensus.

MED19 by CYP19A1 expression — UCEC

Explore this box plot interactively →