CYP19A1

Across TCGA cell cohorts, CYP19A1 mutation is significantly associated with the mutation status of many other genes, with 3,074 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP19A1-associated genes across cancer lineages are DISP2, LAMB4, and DENND3. Each is linked with CYP19A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both CYP19A1-to-partner and partner-to-CYP19A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DISP2 grouped by CYP19A1-low versus CYP19A1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP19A1→partner) and Y-score (partner→CYP19A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DISP2 →	+4.924	+5.584	<.001	<.001	1	4
LARGE_INTESTINE	LAMB4 →	+1.974	+3.801	.004	.004	1	3
LUNG_NSCLC_LUAD	DENND3 →	+4.339	+4.339	.009	.009	1	3
LUNG_NSCLC_LUAD	TIMELESS →	+4.339	+4.339	.009	.009	1	3
LUNG_NSCLC_LUAD	BHLHE41 →	+4.339	+4.339	.009	.009	1	3
LUNG_NSCLC_LUAD	ETS1 →	+5.339	+4.772	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,074 associations by consensus.

DISP2 by CYP19A1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →