CYP11B2

Across TCGA patient cohorts, CYP11B2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYP11B2-associated genes across cancer lineages are 4E-BP1, p38-MAPK_pT180_Y182, and Src_pY527. Each is linked with CYP11B2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CYP11B2-to-partner and partner-to-CYP11B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CYP11B2-low versus CYP11B2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11B2→partner) and Y-score (partner→CYP11B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.285	+3.584	.001	.002	3	3
LUAD	p38-MAPK_pT180_Y182 →	-0.345	-2.000	.023	.031	3	2
LUAD	Src_pY527 →	-0.456	-2.000	.004	.031	3	2
UCEC	eIF4E →	+0.187	+3.598	.009	.001	3	2
UCEC	p62 Lck ligand →	+0.241	+2.459	.029	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.669	+2.459	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

4E-BP1 by CYP11B2 expression — UCEC

Explore this box plot interactively →