CYP11B2

Across TCGA pan-cancer cohorts, CYP11B2 RNA is linked to patient survival in 9 of 34 cancer types, making it the most broadly survival-associated CYP11B2 data layer compared with 5 for mutation status.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CYP11B2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYP11B2 expression acts as an unfavorable survival marker, although some lineages such as ACC show a favorable association.

CESC, DLBC, and BLCA are the cancer types where CYP11B2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	II,III,IV	0.110	0.560	.004	48	view →
DLBC	OS	Tertile	II,III,IV	0.430	0.895	.001	45	view →
BLCA	DFS	Tertile	IV	0.130	0.487	<.001	36	view →
STAD	DFS	Tertile	All	0.327	0.517	.024	36	view →
LUAD	OS	Tertile	III,IV	0.223	0.677	.006	36	view →
SCLC	DFS	Tertile	All	0.274	0.815	.013	18	view →
LIHC	OS	Tertile	II,III,IV	0.235	0.638	.031	12	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	9	view →
ACC	OS	Median	III,IV	0.797	0.420	.043	6	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

CYP11B2–CESC (OS)

Open the CESC breakdown →