CYP11B2

Across TCGA cell cohorts, CYP11B2 mutation is significantly associated with the RNA expression of many other genes, with 116 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYP11B2-associated genes across cancer lineages are PROP1, FAM205A, and OR1P1. Each is linked with CYP11B2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYP11B2-to-partner and partner-to-CYP11B2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by CYP11B2-low versus CYP11B2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYP11B2→partner) and Y-score (partner→CYP11B2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.020	+3.289	.001	.009	3	2
LARGE_INTESTINE	FAM205A →	+0.016	+2.122	<.001	.003	3	2
LUNG_NSCLC_LUAD	OR1P1 →	+0.025	+3.472	<.001	.004	3	2
BLOOD_Leukemia	OR56B4 →	+0.242	+3.453	<.001	.009	3	2
SKIN	KRT73 →	+0.025	+4.467	<.001	.004	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 116 associations by consensus.

PROP1 by CYP11B2 expression — BLOOD_Leukemia

Explore this box plot interactively →