CYLD

Across TCGA patient cohorts, CYLD protein abundance is significantly associated with the RNA expression of many other genes, with 16,213 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CYLD-associated genes across cancer lineages are BTK, BIN2, and SASH3. Each is linked with CYLD in more than 9 cancer types. Because this analysis shows association rather than direction, both CYLD-to-partner and partner-to-CYLD results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYLD versus BTK in OV, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLD→partner) and Y-score (partner→CYLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BTK →	+1.039	+0.445	<.001	<.001	3	10
HNSC	BIN2 →	+1.246	+0.334	<.001	<.001	3	10
OV	SASH3 →	+1.115	+0.396	<.001	<.001	3	10
HNSC	NCKAP1L →	+0.994	+0.280	<.001	<.001	3	10
HNSC	IKZF1 →	+1.115	+0.343	<.001	<.001	3	10
HNSC	LILRB1 →	+0.916	+0.318	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,213 associations by consensus.

CYLD vs BTK — OV

Explore this scatter interactively →