CYLD

Across TCGA patient cohorts, CYLD mutation is significantly associated with the RNA expression of many other genes, with 3,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYLD-associated genes across cancer lineages are PIMREG, UBE2I, and SF3A2. Each is linked with CYLD in more than 3 cancer types. Because this analysis shows association rather than direction, both CYLD-to-partner and partner-to-CYLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIMREG grouped by CYLD-low versus CYLD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLD→partner) and Y-score (partner→CYLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIMREG →	+0.627	+1.480	<.001	<.001	3	4
UCEC	UBE2I →	+0.287	+1.649	<.001	<.001	3	3
UCEC	SF3A2 →	+0.316	+1.491	.001	<.001	3	3
UCEC	LIG1 →	+0.439	+1.839	<.001	<.001	3	3
UCEC	C1QBP →	+0.486	+2.743	<.001	<.001	3	3
UCEC	YWHAE →	+0.267	+1.839	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,739 associations by consensus.

PIMREG by CYLD expression — UCEC

Explore this box plot interactively →