CYLD

Across TCGA patient cohorts, CYLD mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYLD-associated genes across cancer lineages are FASN, PKC-delta_pS664, and GSK-3_pS9. Each is linked with CYLD in more than 2 cancer types. Because this analysis shows association rather than direction, both CYLD-to-partner and partner-to-CYLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by CYLD-low versus CYLD-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLD→partner) and Y-score (partner→CYLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.437	+2.823	.020	.034	3	3
STAD	PKC-delta_pS664 →	-0.133	-2.984	.028	.034	3	3
STAD	GSK-3_pS9 →	-0.587	-3.459	<.001	.005	3	2
STAD	NF-kB-p65_pS536 →	-0.672	-3.459	<.001	.005	3	2
STAD	p38-MAPK_pT180_Y182 →	-0.463	-3.149	.005	.017	3	2
STAD	Src_pY527 →	-0.557	-2.321	.012	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

FASN by CYLD expression — STAD

Explore this box plot interactively →