CYLD

Across TCGA cell cohorts, CYLD RNA expression is significantly associated with the go_rna of many other GO terms, with 6,075 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CYLD-associated GO terms across cancer lineages are Regulation of tumor necrosis factor-mediated signaling pathway, Regulation of post-translational protein modification, and Negative regulation of organelle assembly. Each is linked with CYLD in more than 15 cancer types. Because this analysis shows association rather than direction, both CYLD-to-partner and partner-to-CYLD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of tumor necrosis factor-mediated signaling pathway grouped by CYLD-low versus CYLD-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CYLD→partner) and Y-score (partner→CYLD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of tumor necrosis factor-mediated signaling pathway →	+0.111	+1.881	<.001	<.001	3	16
PANCREAS	Regulation of post-translational protein modification →	+0.050	+0.970	.001	.001	3	15
LUNG_NSCLC_LUSC	Negative regulation of organelle assembly →	+0.116	+1.278	<.001	<.001	3	15
CNS	Regulation of protein modification by small protein conjugation or removal →	+0.051	+1.139	<.001	<.001	3	15
LUNG_SCLC	Necroptotic process →	+0.101	+0.667	<.001	.001	3	15
LUNG_NSCLC_LUSC	Negative regulation of protein modification process →	+0.060	+1.246	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,075 associations by consensus.

Regulation of tumor necrosis factor-mediated signaling pathway by CYLD expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →