CYFIP2

Across TCGA cell cohorts, CYFIP2 mutation is significantly associated with the RNA expression of many other genes, with 921 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYFIP2-associated genes across cancer lineages are PIGY, KSR2, and ZIC5. Each is linked with CYFIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYFIP2-to-partner and partner-to-CYFIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGY grouped by CYFIP2-low versus CYFIP2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYFIP2→partner) and Y-score (partner→CYFIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PIGY →	+2.387	+4.300	<.001	.001	3	2
BLOOD_Leukemia	KSR2 →	+0.446	+3.798	<.001	.004	3	2
LARGE_INTESTINE	ZIC5 →	+1.201	+3.584	<.001	<.001	3	2
URINARY_TRACT	CLLU1-AS1 →	+0.085	+4.087	<.001	.009	3	1
URINARY_TRACT	MPC1L →	+0.062	+4.087	<.001	.009	3	1
URINARY_TRACT	CFAP97D2 →	+0.032	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 921 associations by consensus.

PIGY by CYFIP2 expression — CNS

Explore this box plot interactively →