Q-omics provides the consensus-scored CYCSP55 profile across patient tissues and cancer cell-line models. CYCSP55 expression is associated with patient survival in 17 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, CYCSP55 is differentially expressed in 8, with the highest sampling consensus in KIRC. Additionally, CYCSP55 RNA expression shows 9,077 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KICH, KIRC, and LSCC as cancer lineages where CYCSP55 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CYCSP55 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CYCSP55 survival associations across molecular data types. CYCSP55 RNA expression shows survival associations in the most cancer types (17). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CYCSP55 RNA expression–survival associations across cancer types. High CYCSP55 expression shows unfavorable associations in KICH, UVM, ACC, KIRP and BRCA, but favorable associations in READ. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify KICH as the clearest survival context for CYCSP55 RNA expression.
This table summarizes CYCSP55 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for CYCSP55. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CYCSP55 shows lower tumor expression in KIRC and higher tumor expression in UCEC, COAD, LUSC, HNSC and BRCA. The KIRC box plot shows higher CYCSP55 RNA expression in normal versus tumor tissue (log2 FC = −0.158, t-test p = .001).
This table shows molecular features associated with CYCSP55 in patient tissues and cancer cell lines. In patient samples, CYCSP55 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
