CYCSP4

Across TCGA pan-cancer cohorts, CYCSP4 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated CYCSP4 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CYCSP4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYCSP4 expression acts as an unfavorable survival marker, although some lineages such as BLCA and LAML show a favorable association.

ACC, CHOL, and BLCA are the cancer types where CYCSP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	III,IV	0.010	0.458	<.001	81	view →
CHOL	OS	Tertile	All	0.019	0.800	<.001	54	view →
BLCA	OS	Tertile	III,IV	0.751	0.627	.015	51	view →
LGG	DFS	Tertile	All	0.188	0.417	<.001	36	view →
LAML	DFS	Tertile	All	0.571	0.240	.013	16	view →
GBM	DFS	Tertile	All	0.340	0.217	.013	12	view →
BRCA	DFS	Tertile	IV	0.824	0.232	.025	12	view →
HNSC	DFS	Tertile	III,IV	0.546	0.702	.017	9	view →
COAD	DFS	Tertile	IV	0.125	0.532	.003	9	view →
ESCA	OS	Median	III,IV	0.547	0.323	.025	5	view →
PAAD	OS	Tertile	II,III,IV	0.645	0.408	.047	3	view →
THCA	DFS	Tertile	II,III,IV	1.000	0.842	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

CYCSP4–ACC (DFS)

Open the ACC breakdown →