CYCSP39

Across TCGA pan-cancer cohorts, CYCSP39 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated CYCSP39 data layer.

The strongest signal is observed in thymoma (THYM), where higher CYCSP39 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYCSP39 expression acts as an unfavorable survival marker, although some lineages such as ACC and LAML show a favorable association.

THYM, CHOL, and ACC are the cancer types where CYCSP39 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	II,III,IV	0.708	0.937	<.001	57	view →
CHOL	OS	Tertile	All	0.142	0.761	<.001	57	view →
ACC	OS	Median	III,IV	0.781	0.252	.002	38	view →
ESCA	OS	Median	All	0.370	0.636	.002	36	view →
LUAD	OS	Quartile	All	0.506	0.728	<.001	27	view →
LGG	DFS	Quartile	All	0.641	0.770	.001	27	view →
KIRP	DFS	Tertile	IV	0.038	0.527	.010	24	view →
LIHC	DFS	Tertile	All	0.367	0.565	.022	18	view →
UCS	DFS	Median	All	0.342	0.606	.011	16	view →
LAML	DFS	Tertile	All	0.636	0.325	.048	12	view →
COAD	DFS	Median	All	0.437	0.618	.013	9	view →
SKCM	OS	Quartile	III,IV	0.818	0.625	.015	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

CYCSP39–THYM (DFS)

Open the THYM breakdown →