CYBRD1

Across TCGA pan-cancer cohorts, CYBRD1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CYBRD1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CYBRD1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CYBRD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, CCRCC, and LSCC are the cancer types where CYBRD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.386	0.693	.005	44	view →
CCRCC	DFS	Quartile	All	0.430	0.889	.019	16	view →
LSCC	OS	Median	II,III,IV	0.600	0.873	.015	13	view →
UCEC	DFS	Quartile	II,III,IV	0.235	0.891	.004	12	view →
GBM	OS	Quartile	All	0.758	0.924	.026	2	view →
HNSC	DFS	Quartile	All	0.897	0.799	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CYBRD1–PDAC (OS)

Open the PDAC breakdown →