CYBC1

Across TCGA patient cohorts, CYBC1 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYBC1-associated genes across cancer lineages are GPC6-AS1, OR2AI1P, and ANOS2P. Each is linked with CYBC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYBC1-to-partner and partner-to-CYBC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPC6-AS1 grouped by CYBC1-low versus CYBC1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYBC1→partner) and Y-score (partner→CYBC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	GPC6-AS1 →	+0.063	+4.539	<.001	.008	3	1
CESC	OR2AI1P →	+0.044	+4.669	<.001	.007	3	1
CESC	ANOS2P →	+0.016	+4.539	<.001	.008	3	1
CESC	OR2U2P →	+0.047	+4.969	<.001	.004	3	1
CESC	MIR549A →	+0.336	+5.342	<.001	.002	3	1
CESC	SLC29A4P1 →	+0.050	+4.969	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

GPC6-AS1 by CYBC1 expression — CESC

Explore this box plot interactively →