CYBC1

Across TCGA pan-cancer cohorts, CYBC1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CYBC1 data layer compared with 1 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CYBC1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYBC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

KIRC, HNSC, and ACC are the cancer types where CYBC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.533	0.711	<.001	156	view →
HNSC	OS	Median	II,III,IV	0.433	0.264	<.001	110	view →
ACC	DFS	Median	All	0.527	0.784	<.001	57	view →
SKCM	DFS	Median	All	0.679	0.536	.001	54	view →
KICH	DFS	Median	II,III,IV	0.527	1.000	.001	48	view →
MESO	OS	Tertile	All	0.719	0.411	.002	47	view →
LGG	DFS	Median	All	0.669	0.804	<.001	44	view →
LIHC	DFS	Quartile	All	0.407	0.576	.003	40	view →
BRCA	OS	Quartile	III,IV	0.939	0.808	.006	31	view →
BLCA	OS	Tertile	II,III,IV	0.797	0.645	.003	27	view →
LUSC	OS	Tertile	II,III,IV	0.567	0.730	.006	23	view →
KIRP	DFS	Tertile	II,III,IV	0.333	0.873	.016	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CYBC1–KIRC (DFS)

Open the KIRC breakdown →