CYBB

Across TCGA pan-cancer cohorts, CYBB mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CYBB data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CYBB mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYBB expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

COAD, PDAC, and LSCC are the cancer types where CYBB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.876	1.000	.015	66	view →
PDAC	DFS	Quartile	All	0.294	0.520	.010	8	view →
LSCC	OS	Quartile	All	0.955	0.811	.019	6	view →
LUAD	DFS	Quartile	II,III,IV	0.795	0.382	.045	2	view →
HNSC	DFS	Median	III,IV	0.939	1.000	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CYBB–COAD (DFS)

Open the COAD breakdown →