CYBA

Across TCGA pan-cancer cohorts, CYBA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CYBA data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CYBA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CYBA expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

COAD, PDAC, and CCRCC are the cancer types where CYBA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.918	1.000	.012	60	view →
PDAC	DFS	Quartile	All	0.687	0.878	.010	25	view →
CCRCC	OS	Tertile	IV	0.246	1.000	.049	8	view →
UCEC	DFS	Median	III,IV	0.889	0.460	.044	4	view →
LSCC	OS	Median	III,IV	0.990	0.719	.034	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CYBA–COAD (DFS)

Open the COAD breakdown →