CYB5R4

Across TCGA pan-cancer cohorts, CYB5R4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CYB5R4 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CYB5R4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CYB5R4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where CYB5R4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.904	.008	22	view →
PDAC	OS	Quartile	III,IV	0.227	0.843	.010	10	view →
CCRCC	DFS	Quartile	All	0.880	0.588	.009	6	view →
LUAD	OS	Median	III,IV	0.222	0.627	.027	2	view →
LSCC	DFS	Tertile	II,III,IV	0.700	0.905	.028	1	view →
HNSC	DFS	Median	IV	0.920	1.000	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CYB5R4–UCEC (OS)

Open the UCEC breakdown →