CYB5R4

Across TCGA patient cohorts, CYB5R4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5R4-associated genes across cancer lineages are p62 Lck ligand, Transglutaminase, and FoxM1. Each is linked with CYB5R4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5R4-to-partner and partner-to-CYB5R4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CYB5R4-low versus CYB5R4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R4→partner) and Y-score (partner→CYB5R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.384	+2.169	.001	.003	3	2
LUSC	Transglutaminase →	-0.358	-3.160	.024	.019	3	1
UCEC	FoxM1 →	+0.312	+2.662	.001	<.001	3	1
UCEC	ACC_pS79 →	+0.355	+3.469	.006	.002	2	2
UCEC	Gab2 →	+0.271	+1.765	.043	.014	3	1
UCEC	ACC1 →	+0.341	+2.459	.012	.019	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

p62 Lck ligand by CYB5R4 expression — UCEC

Explore this box plot interactively →