CYB5R3

Across TCGA patient cohorts, CYB5R3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,204 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CYB5R3-associated genes across cancer lineages are IGFBP7, ACTA2, and DCN. Each is linked with CYB5R3 in more than 6 cancer types. Because this analysis shows association rather than direction, both CYB5R3-to-partner and partner-to-CYB5R3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CYB5R3 versus IGFBP7 in HNSC, with a Pearson correlation of 0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R3→partner) and Y-score (partner→CYB5R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IGFBP7 →	+0.881	+0.311	<.001	<.001	3	7
OV	ACTA2 →	+1.712	+0.351	<.001	<.001	3	6
OV	DCN →	+1.723	+0.435	<.001	<.001	3	6
OV	TMEM204 →	+0.725	+0.258	<.001	<.001	3	6
OV	CDH11 →	+1.327	+0.424	<.001	<.001	3	6
HNSC	COX7A1 →	+1.116	+0.223	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,204 associations by consensus.

CYB5R3 vs IGFBP7 — HNSC

Explore this scatter interactively →