CYB5R2

Across TCGA patient cohorts, CYB5R2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5R2-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and ACC_pS79. Each is linked with CYB5R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5R2-to-partner and partner-to-CYB5R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CYB5R2-low versus CYB5R2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R2→partner) and Y-score (partner→CYB5R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.258	-2.222	.015	.011	3	1
UCEC	FoxM1 →	+0.226	+2.906	.039	.001	3	1
UCEC	ACC_pS79 →	+0.391	+2.321	.007	.033	3	1
UCEC	JNK2 →	+0.188	+1.700	.026	.044	3	1
UCEC	Notch1 →	+0.222	+3.183	<.001	.009	3	1
UCEC	p27_pT198 →	+0.090	+1.700	.048	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1068 by CYB5R2 expression — UCEC

Explore this box plot interactively →