CYB5R2

Across TCGA cell cohorts, CYB5R2 mutation is significantly associated with the mutation status of many other genes, with 543 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CYB5R2-associated genes across cancer lineages are EIF4B, ACTB, and CRISPLD2. Each is linked with CYB5R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5R2-to-partner and partner-to-CYB5R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EIF4B grouped by CYB5R2-low versus CYB5R2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R2→partner) and Y-score (partner→CYB5R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EIF4B →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	ACTB →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	CRISPLD2 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	BFAR →	+3.744	+4.044	.003	.003	1	2
LARGE_INTESTINE	NCS1 →	+4.329	+4.329	.001	.001	1	2
LARGE_INTESTINE	CAMKK2 →	+3.329	+3.799	.005	.005	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 543 associations by consensus.

EIF4B by CYB5R2 expression — LARGE_INTESTINE

Explore this box plot interactively →