CYB5R1

Across TCGA pan-cancer cohorts, CYB5R1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CYB5R1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CYB5R1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CYB5R1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where CYB5R1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.976	0.851	.004	12	view →
LSCC	DFS	Quartile	II,III,IV	0.471	0.929	.005	11	view →
UCEC	DFS	Quartile	All	1.000	0.800	.009	10	view →
HNSC	DFS	Median	III,IV	0.901	0.706	.013	7	view →
GBM	OS	Quartile	All	0.922	0.929	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CYB5R1–CCRCC (DFS)

Open the CCRCC breakdown →