CYB5R1

Across TCGA pan-cancer cohorts, CYB5R1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CYB5R1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CYB5R1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYB5R1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, LIHC, and THCA are the cancer types where CYB5R1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYB5R1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−1.098	<.001	11	view →
LIHC	Female	II,III,IV	+1.384	<.001	9	view →
THCA	All	IV	−0.860	<.001	9	view →
HNSC	Female	III,IV	+1.187	.002	7	view →
STAD	Male	IV	−0.849	.005	7	view →
BRCA	All	III,IV	+0.779	<.001	6	view →
CHOL	All	All	+1.488	<.001	3	view →
KIRP	All	All	−0.454	.017	2	view →
PRAD	All	All	−0.193	.039	2	view →
ESCA	All	All	−0.629	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CYB5R1–KICH

Open the KICH breakdown →