CYB5R1

Across TCGA patient cohorts, CYB5R1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5R1-associated genes across cancer lineages are Notch1, p38-MAPK, and PREX1. Each is linked with CYB5R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5R1-to-partner and partner-to-CYB5R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CYB5R1-low versus CYB5R1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5R1→partner) and Y-score (partner→CYB5R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.156	+2.459	.021	.020	3	2
UCEC	p38-MAPK →	-0.187	-2.459	.018	.020	3	1
UCEC	PREX1 →	-0.293	-3.169	.027	.019	3	1
UCEC	TSC1 →	-0.249	-2.459	.002	.020	2	1
UCEC	ATM →	-0.718	-3.584	.001	.002	2	1
UCEC	FoxM1 →	+0.286	+2.459	.022	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Notch1 by CYB5R1 expression — UCEC

Explore this box plot interactively →