CYB5B

Across TCGA patient cohorts, CYB5B mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CYB5B-associated genes across cancer lineages are SNORD116-19, RNA5SP91, and RN7SL655P. Each is linked with CYB5B in more than 1 cancer types. Because this analysis shows association rather than direction, both CYB5B-to-partner and partner-to-CYB5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-19 grouped by CYB5B-low versus CYB5B-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CYB5B→partner) and Y-score (partner→CYB5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SNORD116-19 →	+0.488	+3.719	<.001	.008	3	1
BLCA	RNA5SP91 →	+0.291	+3.840	.001	.006	3	1
CESC	RN7SL655P →	+0.142	+5.418	<.001	.005	3	1
CESC	RNU6-1191P →	+1.483	+5.103	<.001	.008	3	1
UCEC	ADAM33 →	-0.939	-3.406	.007	.005	3	1
UCEC	NUDT22 →	+0.451	+3.716	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

SNORD116-19 by CYB5B expression — BLCA

Explore this box plot interactively →