CYB5B

Across TCGA pan-cancer cohorts, CYB5B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CYB5B data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CYB5B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CYB5B expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

HNSC, ACC, and KIRC are the cancer types where CYB5B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.256	0.439	<.001	160	view →
ACC	DFS	Tertile	All	0.148	0.645	<.001	51	view →
KIRC	DFS	Tertile	All	0.854	0.687	.005	48	view →
LIHC	DFS	Tertile	All	0.444	0.619	<.001	44	view →
LGG	OS	Median	All	0.741	0.878	<.001	37	view →
COAD	OS	Median	IV	0.699	0.376	.003	36	view →
LUAD	DFS	Quartile	All	0.573	0.741	.001	28	view →
PAAD	DFS	Quartile	All	0.311	0.672	.002	20	view →
PRAD	DFS	Tertile	All	0.898	0.706	.002	18	view →
STAD	OS	Tertile	II,III,IV	0.730	0.553	.007	17	view →
THCA	DFS	Tertile	All	0.900	0.764	.008	14	view →
UCS	DFS	Tertile	III,IV	0.156	0.528	.029	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CYB5B–HNSC (OS)

Open the HNSC breakdown →