CYB561D1

Across TCGA pan-cancer cohorts, CYB561D1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CYB561D1 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CYB561D1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CYB561D1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

HNSC, KICH, and ACC are the cancer types where CYB561D1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.840	0.690	<.001	91	view →
KICH	OS	Tertile	II,III,IV	0.604	1.000	.003	86	view →
ACC	DFS	Tertile	All	0.189	0.750	<.001	81	view →
LIHC	OS	Median	All	0.603	0.763	<.001	76	view →
PAAD	OS	Median	All	0.597	0.384	<.001	57	view →
KIRC	DFS	Median	All	0.733	0.539	<.001	49	view →
STAD	DFS	Tertile	All	0.737	0.512	<.001	40	view →
LGG	DFS	Median	All	0.310	0.510	<.001	32	view →
LUAD	DFS	Tertile	IV	0.404	0.721	.015	18	view →
CHOL	DFS	Quartile	All	0.731	0.107	.017	15	view →
ESCA	OS	Median	IV	0.698	0.222	.006	12	view →
THYM	DFS	Tertile	III,IV	1.000	0.348	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CYB561D1–HNSC (OS)

Open the HNSC breakdown →