CYB561D1

Across TCGA pan-cancer cohorts, CYB561D1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CYB561D1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CYB561D1 RNA is repressed in tumor relative to normal tissue. In most cancer types CYB561D1 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LIHC, and LUAD are the cancer types where CYB561D1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CYB561D1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.708	<.001	11	view →
LIHC	Female	II,III,IV	+1.431	<.001	9	view →
LUAD	Female	II,III,IV	−0.929	<.001	8	view →
BRCA	All	All	−0.636	<.001	6	view →
THCA	All	All	−0.345	<.001	6	view →
CHOL	Female	All	+2.733	<.001	5	view →
READ	All	II,III,IV	−0.787	.002	5	view →
KICH	All	All	−0.554	<.001	5	view →
UCEC	All	All	−0.654	.001	2	view →
KIRC	Male	II,III,IV	−0.337	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CYB561D1–COAD

Open the COAD breakdown →