CXorf21

Across TCGA patient cohorts, CXorf21 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXorf21-associated genes across cancer lineages are Cyclin-B1, Shc_pY317, and EGFR_pY1173. Each is linked with CXorf21 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXorf21-to-partner and partner-to-CXorf21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CXorf21-low versus CXorf21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXorf21→partner) and Y-score (partner→CXorf21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.762	+3.906	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.155	-1.807	.004	.025	3	2
SKCM	EGFR_pY1173 →	+0.113	+3.012	.014	.018	3	1
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.590	+3.459	.031	.005	3	1
UCEC	eEF2 →	+0.322	+1.925	.012	.005	3	1
UCEC	EGFR_pY1068 →	-0.283	-1.925	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Cyclin-B1 by CXorf21 expression — UCEC

Explore this box plot interactively →