CXorf21

Across TCGA pan-cancer cohorts, CXorf21 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CXorf21 data layer compared with 1 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CXorf21 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CXorf21 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and LUAD are the cancer types where CXorf21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.410	0.263	<.001	121	view →
HNSC	DFS	Median	All	0.766	0.652	<.001	100	view →
LUAD	DFS	Median	All	0.755	0.579	<.001	66	view →
UVM	DFS	Tertile	III,IV	0.208	0.683	.011	46	view →
CESC	DFS	Quartile	II,III,IV	0.868	0.584	.005	38	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
LGG	OS	Median	All	0.365	0.530	<.001	35	view →
KIRC	DFS	Quartile	III,IV	0.808	0.485	.023	24	view →
ACC	DFS	Quartile	II,III,IV	0.745	0.152	.011	12	view →
LAML	DFS	Tertile	All	0.420	0.688	.013	12	view →
LIHC	OS	Tertile	III,IV	0.403	0.738	.002	11	view →
SARC	OS	Tertile	All	0.825	0.647	.002	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CXorf21–SKCM (OS)

Open the SKCM breakdown →