CXXC5

Across TCGA patient cohorts, CXXC5 mutation is significantly associated with the RNA expression of many other genes, with 553 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXXC5-associated genes across cancer lineages are OR5AN1, PARP2, and RN7SL369P. Each is linked with CXXC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXXC5-to-partner and partner-to-CXXC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5AN1 grouped by CXXC5-low versus CXXC5-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXXC5→partner) and Y-score (partner→CXXC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR5AN1 →	+0.041	+6.468	<.001	.001	3	2
UCEC	PARP2 →	+0.515	+2.633	.003	.005	3	2
COAD	RN7SL369P →	+0.093	+4.418	.001	.008	3	2
UCEC	CCDC58P3 →	+0.261	+2.302	.004	.008	3	2
UCEC	COX10 →	+0.440	+2.539	.004	.009	3	2
SCLC	HTN1 →	+0.387	+4.847	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 553 associations by consensus.

OR5AN1 by CXXC5 expression — HNSC

Explore this box plot interactively →