CXXC5

Across TCGA pan-cancer cohorts, CXXC5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CXXC5 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CXXC5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CXXC5 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

UVM, MESO, and KIRP are the cancer types where CXXC5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.388	0.759	<.001	93	view →
MESO	OS	Tertile	II,III,IV	0.383	0.699	.005	58	view →
KIRP	DFS	Quartile	All	0.830	0.980	.004	58	view →
UCEC	OS	Median	All	0.544	0.842	<.001	56	view →
LGG	OS	Tertile	All	0.385	0.593	<.001	48	view →
LUSC	DFS	Tertile	II,III,IV	0.285	0.494	.005	42	view →
BRCA	DFS	Tertile	III,IV	0.941	0.823	.001	36	view →
LIHC	DFS	Tertile	All	0.446	0.661	<.001	35	view →
LUAD	OS	Median	All	0.246	0.472	.003	26	view →
SKCM	OS	Tertile	III,IV	0.534	0.209	.004	20	view →
COAD	OS	Quartile	II,III,IV	0.651	0.368	.008	19	view →
READ	DFS	Median	II,III,IV	0.218	0.635	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CXXC5–UVM (DFS)

Open the UVM breakdown →