CXXC5

Across TCGA patient cohorts, CXXC5 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CXXC5-associated genes across cancer lineages are EGFR, eIF4E, and GSK-3a-b_pS21_S9. Each is linked with CXXC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXXC5-to-partner and partner-to-CXXC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by CXXC5-low versus CXXC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXXC5→partner) and Y-score (partner→CXXC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.179	-3.169	.016	.019	3	1
UCEC	eIF4E →	+0.226	+2.321	.021	.034	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.566	+2.999	.004	.035	3	1
UCEC	MEK1 →	+0.470	+3.459	.005	.005	3	1
UCEC	Myosin-IIa_pS1943 →	+0.211	+2.598	.028	.006	3	1
UCEC	p27 →	+0.210	+2.459	.039	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR by CXXC5 expression — UCEC

Explore this box plot interactively →