CXXC5

Across TCGA cell cohorts, CXXC5 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CXXC5-associated genes across cancer lineages are OR10W1, SLC32A1, and CACNG1. Each is linked with CXXC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CXXC5-to-partner and partner-to-CXXC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by CXXC5-low versus CXXC5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CXXC5→partner) and Y-score (partner→CXXC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.019	+4.977	<.001	.007	3	1
BLOOD_Leukemia	SLC32A1 →	+0.602	+3.901	<.001	.006	3	1
BLOOD_Leukemia	CACNG1 →	+0.087	+3.881	<.001	.006	3	1
BLOOD_Leukemia	PHOX2B →	+0.024	+4.365	<.001	.002	3	1
BLOOD_Leukemia	IRX4 →	+0.152	+4.469	<.001	.001	3	1
BLOOD_Leukemia	RFPL3 →	+0.037	+4.339	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

OR10W1 by CXXC5 expression — LARGE_INTESTINE

Explore this box plot interactively →