CXXC5-AS1

Across TCGA pan-cancer cohorts, CXXC5-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CXXC5-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CXXC5-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CXXC5-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

KIRC, UVM, and READ are the cancer types where CXXC5-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.722	0.559	<.001	119	view →
UVM	DFS	Tertile	All	0.250	0.799	.001	60	view →
READ	OS	Tertile	II,III,IV	0.974	0.448	.001	54	view →
HNSC	DFS	Median	IV	0.410	0.149	.013	38	view →
THYM	DFS	Tertile	II,III,IV	1.000	0.502	.005	36	view →
LIHC	OS	Median	II,III,IV	0.308	0.566	.006	33	view →
UCEC	OS	Median	All	0.896	0.945	.003	30	view →
KICH	OS	Median	II,III,IV	0.761	1.000	.007	29	view →
PAAD	OS	Median	All	0.509	0.315	.002	28	view →
COAD	DFS	Median	All	0.711	0.843	.002	27	view →
BRCA	OS	Median	III,IV	0.944	0.865	.003	22	view →
ACC	DFS	Median	IV	0.515	0.220	.018	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CXXC5-AS1–KIRC (OS)

Open the KIRC breakdown →