CXXC5-AS1

Across TCGA pan-cancer cohorts, CXXC5-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of CXXC5-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where CXXC5-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CXXC5-AS1 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

LIHC, KIRP, and KIRC are the cancer types where CXXC5-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXXC5-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	All	III,IV	+0.127	<.001	9	view →
KIRP	Male	All	−0.272	.002	4	view →
KIRC	Female	All	+0.175	.006	3	view →
COAD	All	All	+0.105	.024	3	view →
KICH	Male	All	−0.423	.014	2	view →
CHOL	All	All	+0.201	.014	1	view →
BLCA	Female	IV	+0.120	<.001	1	view →
HNSC	Male	IV	−0.059	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

CXXC5-AS1–LIHC

Open the LIHC breakdown →